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县市场监督管理局：跨区域执法督查药品安全_我的网站
A | 本报讯 闫谨 特约记者张振贺报道 近日，县市场监督管理局药品安全监管相关执法人员开展了乡镇分局跨区域执法监督检查。
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Chinese researchers have developed a multifunctional electrode coating that addresses key challenges in long-term brain-computer interface (BCI) implantation, including signal loss and tissue adhesion, bringing BCI one step closer to clinical application, the Global Times learned from the research team behind the findings on Sunday.
As an emerging field combining neuroscience and artificial intelligence (AI), BCI faces a major challenge of ensuring long-term compatibility between electrodes and brain tissue. Previous clinical trials showed that immune responses could cause implanted electrodes to retract after just three months, severely reducing signal quality and the number of available channels.
This problem stems from chronic inflammation triggered by implants, which creates insulating scar tissue around electrodes and separates them from neurons. Irreversible adhesion between electrodes and brain tissue after long-term implantation also makes device removal risky, potentially causing brain injury during follow-up surgeries.
Experiments showed that flexible neural electrodes coated with this material could operate stably in the brain for more than 300 days and could be safely removed without causing damage. This means the universal coating technology can make electrodes not only operate stably over the long term but can also be safely removed and replaced after aging, paving the way for long-term BCI applications.
Developed by the research team led by Zhang Wei at the Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, associated with Beijing Tiantan Hospital, Shanghai Institute of Microsystem and Information Technology and NeuroXess, a high-tech life science company specializing in BCI technologies, the cationic alternating peptide electrode coating preserves electrode flexibility and conductivity, while offering antibacterial, anti-protein adsorption and immune-rejection-inhibiting functions.
A 300-day animal study showed the coating's effectiveness. Bare electrodes experienced a sharp loss of recording capability after 90 days of implantation and could barely detect neuronal signals after 300 days. In contrast, coated electrodes maintained stable recording channels and consistently captured neural signals above 155 microvolts.
In terms of neural modulation, after 300 days of implantation, conventional electrodes required a current of 100 microamps to induce weak limb responses, while coated electrodes triggered clear movements with only 2 microamps, improving modulation efficiency by 50 times.
Notably, the removal tests highlighted a key advantage of the coating that electrodes no longer form irreversible bonds with brain tissue. In the experiments, the coated electrodes were removed intact, with minimal damage to the surrounding brain tissue, Zhang told the Global Times on Sunday.
。 此次检查重点围绕药品经营企业的设施与设备，药品销售记录，药品陈列与储存条件及质量管理体系文件等方面。
C | 对发现的问题和隐患提出整改意见，当场下达责令改正通知书，并督促相关药品经营企业对存在的问题限时完成整改。 据介绍，县市场监督管理局自采用分局跨区域执法、主管领导交叉督查的监管模式以来，公正文明执法氛围日渐增强，相互监督、相互促进的执法目标迅速达成。同时，通过实施互检互监，有力地促进了市场监管行风建设。年初以来，共计检查药品经营企业134家，药品使用单位100家，网售零售企业28家，血液制品经营企业3家，疫苗接种单位20家，疾病预防控制机构1家，执法人员全员参与，有力有序推进药品安全巩固提升行动。
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